Therapeutic Considerations

- Literature Encyclopaedia -

International Published Data

GMCD Instructional  Course Lectures

Author :  

Dr. med. Guy M.C. Declerck MD (GMCD)

Medical FRCS-, FRCS Ed Orth-, M Ch Orth-, PhD-studies

Spinal Surgical and Research Fellow, Perth, Western Australia

Spinal Orthopaedic Surgeon and Surgical Instructor

Consultant R&D Innovative & Restorative Spinal Technologies

President International Association of Andullation Technology (IAAT)

Literature Encyclopaedia


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Regenerative potential of TGFbeta3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells

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The role of activity in the therapeutic management of back pain. Report of the International Paris Task Force on back pain

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Abitbol JJ        Complications in spine surgery

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Complications associated with epidural steroid injections

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Drugs for pain. Treatment Guidelines

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Gradual disc prolapse

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The effect of posture on the role of the apophysial joints in resisting intervertebral compressive forces

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The relevance of torsion to the mechanical derangement of the lumbar spine

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Effects of backward bending on lumbar intervertebral discs. Relevance to physical therapy treatments for low back pain
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What is intervertebral disc degeneration, and what causes it?

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Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion

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Phishing for Phools

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Albee FH        Transplantation of a portion of the tibia into the spine for Pott's disease. A preliminary report

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Albert TJ        

Spinal Instrumentation

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The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix

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Relevance of in vitro and in vivo models for intervertebral disc degeneration

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Intervertebral disc degeneration. Biological and biomechanical factors

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Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits

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Biological repair of intervertebral disc

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Anderson DG, Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ

Cell-based therapy for disc repair

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Intervertebral disc arthroplasty

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Intradiskal pressure, intra-abdominal pressure and myoelectric back muscle activity related to posture and loading
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Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains

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Spinal manipulative therapy for low back pain. A meta-analysis of effectiveness relative to other therapies

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Dynamic genome engineering in living cells

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Axelsson P, Johnsson R, Strömqvist B

Effect of lumbar orthosis on intervertebral mobility. A roentgen stereophotogrammetric analysis

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Axelsson P, Johnsson R, Strömqvist B

Lumbar orthosis with unilateral hip immobilization. Effect on intervertebral mobility determined by roentgen stereophotogrammetric analysis

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Posterolateral lumbar fusion. Outcome of 71 consecutive operations after 4 (2-7) years

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Badylak SF, Taylor D, Uygun K

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Baiguera S, Jungebluth P, Burns A, Mavilia C, Haag J, De Coppi P, Macchiarini P

Tissue engineered human tracheas for in vivo transplantation

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Freeman TC, Mattick JS, Hume DA, Heutink P, Carninci P, Jeddeloh JA, Faulkner GJ

Somatic retrotransposition alters the genetic landscape of the human brain

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Clinical update. Low back pain

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Baltzer AW, Lieberman JR

Regional gene therapy to enhance bone repair

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Bao QB, McCullen GM, Higham PA, Dumbleton JH, Yuan HA

The artificial disc. Theory, design and materials

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New Technologies in Spine. Nucleus Replacement

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Randomized controlled trial of percutaneous intradiscal radiofrequency thermocoagulation for chronic discogenic back pain. Lack of effect from a 90-second 70 C lesion

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Barker BR        How do we know that the placebo effect exists

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Bartels EM, Fairbank JC, Winlove CP, Urban JP

Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with

scoliosis and back pain

Spine, 1998, 23:1

Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA

Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation

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Evaluation of the mobility of adjacent segments after posterior thoracolumbar fixation. A biomechanical study
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Battié MC, Haynor DR, Fisher LD, Gill K, Gibbons LE, Videman T        

Similarities in degenerative findings on magnetic resonance images of the lumbar spines of identical twins

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Battié MC, Videman T        

Lumbar disc degeneration. Epidemiology and genetics

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Battié MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K        

1995 Volvo award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins

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Lumbar disc degeneration. Epidemiology and genetic influences

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Genetic and environmental effects on disc degeneration by phenotype and spinal level. A multivariate twin study

Spine, 2008, 33:2801

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Bone graft materials. An overview of the basic science

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Proteoglycan synthesis in the human intervertebral disc. Variation with age, region and pathology. 1988 Volvo award in basic science

Spine, 1988, 13:972

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Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures

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Measurement of subjective responses. Quantitative effect of drugs

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Beecher HK

The powerful placebo

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Correlation of radiographic and MRI parameters to morphological and biochemical assessment of intervertebral disc degeneration

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Adipocytic cells cultured from marrow have osteogenic potential

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Osteogenic stem cells and the stromal system of bone and marrow

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Total disc replacement compared to lumbar fusion. A randomised controlled trial with 2-year follow-up

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Endoscopic lateral transpsoas approach to the lumbar spine

Spine, 2004, 29:1681

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Indication for full prosthetic disc arthroplasty. A correlation of clinical outcome against a variety of indications

Eur Spine J, 2002, 11(Suppl 2):S131

Bertram H, Kroeber M, Wang H, Unglaub F, Guehring T, Carstens C, Richter W

Matrix-assisted cell transfer for intervertebral disc cell therapy

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Bhatia NN, Lee KH, Bui CN, Luna M, Wahba GM, Lee TQ

Biomechanical evaluation of an expandable cage in single-segment posterior lumbar interbody fusion

Spine, 2012, 37:E79

Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B

Sox9 is required for cartilage formation

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Cell viability in scoliotic discs in relation to disc deformity and nutrient levels

Spine, 2002, 27:2220

Bibby SR, Urban JP

Effect of nutrient deprivation on the viability of intervertebral disc cells

Eur Spine J, 2004, 13:695

Biering-Sørensen F

Physical measurements as risk indicators for low-back trouble over a one-year period

Spine, 1984, 9:106

Birchall MA, Seifalian AM

Tissue engineering’s green shoots of disruptive innovation

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Blackburn EH, Greider CW, Szostak JW

How chromosomes are protected by telomeres and the enzyme telomerase

The Nobel Prize in Physiology or Medicine 2009

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Isolation and characterization of mesenchymal stromal cells from human degenerated nucleus pulposus. Comparison with bone marrow mesenchymal stromal cells from the same subjects

Spine, 2010, 35:2259

Blau H

A twist a fate

Nature, 202, 419:437

Blumenthal SL, Baker J, Dossett A, Selby DK

The role of anterior lumbar fusion for internal disc disruption

Spine 1988, 13:566

Blumenthal SL, McAfee PC, Guyer RD, Hochschuler SH, Geisler FH, Holt RT, Garcia R Jr, Regan JJ, Ohnmeiss DD

A prospective, randomized, multicenter Food and Drug Administration investigational device exemptions study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion. Part I: evaluation of clinical outcomes

Spine, 2005, 30:156

Boden SD        

Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute
Spine, 2002, 27(Suppl 1):S26

Boden SD, Balderston RA, Heller JG, Hanley EN Jr, Zigler JE

An AOA critical issue. Disc replacements. This time will we really cure low-back and neck pain?

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Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW

Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation

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Boden SD, Kang J, Sandhu H, Heller JG

Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans. A prospective, randomized clinical pilot trial. 2002 Volvo Award in clinical studies

Spine, 2002, 27:2662

Boden SD, Titus L, Hair G, Liu Y, Viggeswarapu M, Nanes MS, Baranowski C

Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1)

Spine, 1998, 23:2486

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The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans. A preliminary report

Spine, 2000, 25:376

Bogdanffy GM, Ohnmeiss DD, Guyer RD

Early changes in bone mineral density above a combined anteroposterior L4-S1 lumbar spinal fusion. A clinical investigation
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Therapeutic acupuncture in the People's Republic of China implications for American medicine

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Spine, 2007, 32:417

Bono CM, Lee CK

Critical analysis of trends in fusion for degenerative disc disease over the past 20 years. Influence of technique on fusion rate and clinical outcome

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The influence of subdiagnosis on radiographic and clinical outcomes after lumbar fusion for degenerative disc disorders. An analysis of the literature from two decades

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Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration

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Nature Outlook Biomaterials. Web of intrigue

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Bouxsein ML, Turek TJ, Blake CA, D’Augusta D, Li X, Stevens M, Seeherman HJ, Wozney JM

Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model

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Brantigan JW, Steffee AD, Geiger JM

A carbon fiber implant to aid interbody lumbar fusion. Mechanical testing
Spine, 1991, 16(Suppl 6):S277

Brau SA        Mini-open approach to the spine for anterior lumbar interbody fusion. Description of the procedure, results and


Spine J, 2002, 2:216

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Surgical results after soft system stabilization of the lumbar spine in degenerative disc disease--long-term results

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A global scientific challenge. Learning the right lessons from ancient healing practices

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Deformation of the vertebral end-plate under axial loading of the spine

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Change of disc height, radial disc bulge, and intradiscal pressure from discectomy. An in vitro investigation on human lumbar discs

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Acupuncture in patients with chronic low back pain. A randomized controlled trial

Arch Intern Med, 2006, 166:450

Brisby H, Tao H, Ma DD, Diwan AD

Cell therapy for disc degeneration. Potentials and pitfalls

Orthop Clin North Am, 2004, 35:85

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Nonoperative management of low back pain and lumbar disc degeneration

J Bone Joint Surg, 2004, 86A:1810

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Nonsteroidal anti-inflammatory drugs. Differences and similarities

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Brox JI, Reikerås O, Nygaard Ø, Sørensen R, Indahl A, Holm I, Keller A, Ingebrigtsen T, Grundnes O, Lange JE, Friis A

Lumbar instrumented fusion compared with cognitive intervention and exercises in patients with chronic back pain after previous surgery for disc herniation. A prospective randomized controlled study

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Randomized clinical trial of lumbar instrumented fusion and cognitive intervention and exercises in patients with chronic low back pain and disc degeneration

Spine, 2003, 28:1913

Bruder SP, Jaiswa N, Ricalton NS, Mosca JD, Kraus KH, Kadiyala S

Mesenchymal stem cells in osteobiology and applied bone regeneration

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Adipose-derived stem cells. Isolation, expansion and differentiation

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Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators

J Bone Joint Surg, 2002, 84B:196

Burkus JK        Interbody fusion devices. Biomechanics and clinical outcomes

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Vaccaro RA, Betz RR, Zeidman SM (eds)

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Burkus JK, Sandhu HS, Gornet MF, Longley MC

Use of rhBMP-2 in combination with structural cortical allografts. Clinical and radiographic outcomes in anterior lumbar spinal surgery

J Bone Joint Surg, 2005, 87A:1205

Burkus JF, Transfelt EE, Kitchel SH, Watkins RG, Balderston RA

Clinical and radiographic outcomes of anterior interbody fuison using recombinant human bone morphogenetic protein-2

Spine, 2002, 27:2396

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An operation for spondylolisthesis

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Acupuncture. A novel hypothesis for the involvement of purinergic signaling

Med Hypotheses, 2009, 73:470

Burnstock G

Purinergic signaling in acupuncture

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Studies in the transplantation of bone. 8 Treated composite homograft-autografts of cancellous bone. An analysis of inductive mechanisms in bone transplantation

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The fate of bone graft

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The function of bone marrow in the incorporation of a bone graft

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The impact of biomechanics in tissue engineering and regenerative medicine

Tissue Eng Part B Rev, 2009, 15:477

Butler DS        

Mobilisation of the nervous system

Churchill Livingstone, Melbourne, 1991

Burton CV, Kirkaldy-Willis WH, Yong-Hing K, Heithoff KB

Causes of failure of surgery on the lumbar spine

Clin Orthop Relat Res, 1981, 157:191

Burton CV

Causes of failure of surgery on the lumbar spine. Ten-year follow-up

Mt Sinai J Med, 1991, 58:183

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The effect of spinal steroid injections for degenerative disc disease

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Die funktionelle Zwischenwirbelendoprothetik SB Charité. Implantatentwicklung, Biomechanik, Patientenanalyse, Perspektive. Dissertationsarbeit der Humbolt-Universität, Berlin, 1889

Büttner-Janz K

The development of the artificial disc SB Charité

Hundley & Associates Inc, Dallas, USA, 1992

Büttner-Janz K, Schellnack K, Zippel H

Biomechanics of the SB Charité lumbar intervertebral disc endoprosthesis

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Eine alternative Behandlungsstrategie beim lumbalen Bandscheibenschaden mit der Bandscheibenendoprothese Modulartyp SB Charité

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Büttner-Janz K, Schellnack K, Zippel H, Conrad P

Experience and results with the SB Charité lumbar intervertebral prosthesis

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Strength and fitness and subsequent back injuries in firefighters

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Caplan AI        


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Caplan AI        

Mesenchymal stem cells

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Caplan Al, Bruder SP

Mesenchymal stem cells. Building blocks for molecular medicine in the 21st century

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New developments in nucleus pulposus replacement technology

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