Therapeutic Considerations

- Literature Encyclopaedia -

International Published Data

GMCD Instructional  Course Lectures

Author :  

Dr. med. Guy M.C. Declerck MD (GMCD)

Medical FRCS-, FRCS Ed Orth-, M Ch Orth-, PhD-studies

Spinal Surgical and Research Fellow, Perth, Western Australia

Spinal Orthopaedic Surgeon and Surgical Instructor

Consultant R&D Innovative & Restorative Spinal Technologies

President International Association of Andullation Technology (IAAT)

Literature Encyclopaedia


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Abnormalities in human pluripotent cells due to reprogramming mechanisms

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Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads

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Superficial acupuncture in the relief of chronic low back pain

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Outcome of the Graf ligamentoplasty procedure compared with anterior lumbar interbody fusion with the Hartshill horseshoe cage

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Molecular and genetic advances in the regeneration of the intervertebral disc

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Gene therapy death prompts review of adenovirus vector

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Masuda K        

Biological repair of the degenerated intervertebral disc by the injection of growth factors

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Prevention of disc degeneration with growth factors

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Masuda K, Imai Y, Okuma M, Muehleman C, Nakagawa K, Akeda K, Thonar E, Andersson G, An HS

Osteogenic protein-1 (OP-1) injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit annular puncture model

Spine, 2006, 31:742

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New challenges for intervertebral disc treatment using regenerative medicine

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Growth factors and treatment of intervertebral disc degeneration

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Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads

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Haematopoietic chimera in man after allogenic (homologous) bone-marrow transplantation

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Osteogenic protein-1 gene. Gene gun transfer to intervertebral disc cells

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Articular cartilage repair with autologous bone marrow mesenchymal cells

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Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs

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Minimally invasive total disc replacement. Surgical technique and preliminary clinical results

Eur Spine J, 2002, 11(Suppl 2):S124

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A prospective short-term study of chronic low back pain patients utilizing novel objective functional measurement

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Contemporary conservative care for painful spinal disorders

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A prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion. Part II. Evaluation of radiographic outcomes and correlation of surgical technique accuracy with clinical outcomes

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Experimental design of total disk replacement-experience with a prospective randomized study of the SB Charité
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Minimally invasive anterior retroperitoneal approach to the lumbar spine. Emphasis on the lateral BAK

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Modeling nucleus pulposus regeneration in vitro. Mesenchymal stem cells, alginate beads, hypoxia, bone morphogenetic protein-2, and synthetic peptide B2A

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McKay R        

Stem cells – hype and hope

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McLain RF, Fleming JF, Boehm CA, Muschler GF

Aspiration of osteoprogenitor cells for augmenting spinal fusion. Comparison of progenitor cell concentrations from the vertebral body and iliac crest

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Trunk strengths in attempted flexion, extension, and lateral bending in healthy subjects and patients with low-back disorders

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Mendelson G, Kidson MA, Loh ST, Scott DF, Selwood TS, Kranz H

Acupuncture analgesia for chronic low back pain

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McClellan JW, Mulconrey DS, Forbes RJ, Fullmer N

Vertebral bone resorption after transforaminal lumbar interbody fusion with bone morphogenetic protein (rhBMP-2)

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McGill SM

Low back stability. From formal description to issues for performance and rehabilitation

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McKenzie AH

Fernström intervertebral disc arthroplasty. A long-term evaluation

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McKenzie RA

Prophylaxis in recurrent low back pain

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McLain RF, Boehm CA, Rufo-Smith C, Muschler GF

Transpedicular aspiration of osteoprogenitor cells from the vertebral body. Progenitor cell concentrations affected by serial aspiration

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McLain RF, Fleming JF, Boehm CA, Muschler GF

Aspiration of osteoprogenitor cells for augmenting spinal fusion. Comparison of progenitor cell concentrations from the vertebral body and iliac crest

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Meakin JR, Hukins DWL

Effect of removing the nucleus pulposus on the deformation of the annulus fibrosus during compression of the intervertebral disc

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Meisel HJ,  Ganey T, Hutton WC, Libera J, Minkus Y, Alasevic O

Clinical experience in cell-based therapeutics. Intervention and outcome

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Meisel HJ, Siodla V, Ganey T, Minkus Y, Hutton WC, Alasevic OJ

Clinical experience in cell-based therapeutics. Disc chondrocyte transplantation. A treatment for degenerated or damaged intervertebral disc

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Melrose J, Smith S, Little CB, Kitson J, Hwa SY, Ghosh P

Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix repair

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Melzack R, Wall PD

Pain mechanisms. A new theory

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Mendes SC, Robin C, Dzierzak E

Mesenchymal progenitor cells localize within hematopoietic sites throughout ontogeny

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Meyer PR        

Surgery of spine trauma

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Millisdotter M, Strömqvist B

Early neuromuscular customized training after surgery for lumbar disc herniation: a prospective controlled study

Eur Spine J, 2007, 16:19

Mimura M, Panjabi MM, Oxland TR, Crisco JJ, Yamamoto I, Vasavada A

Disc degeneration affects the multidirectional flexibility of the lumbar spine

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Minamide A, Hashizume H, Yoshida M, Kawakami M, Hayashi N, Tamaki T

Effects of basic fibroblast growth factor on spontaneous resorption of herniated intervertebral discs. An experimental study in the rabbit

Spine, 1999, 24:940

Minns RJ, Walsh WK

Preliminary design and experimental studies of a novel soft implant for correcting sagittal plane instability in the lumbar spine

Spine, 1997, 22:1819

Mirza SK        

Point of view. Commentary on the research reports that led to food and drug administration approval of an artificial disc

Spine, 2005, 30:1561

Mirza SK, Deyo RA

Systematic review of randomized trials comparing lumbar fusion surgery to nonoperative care for treatment of chronic back pains

Spine, 2007, 32:816

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Accuracy of thoracic vertebral body screw placement using standard fluoroscopy, fluoroscopic guidance, and computer tomographic image guidance. A cadaver study

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Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage

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Mitchell RI, Carmen GM

The functional restoration approach to the treatment of chronic pain in patients with soft tissue and back injuries

Spine, 1994,19:633

Miyake T, Kalluri R

Cell plasticity helps hearts to repair

Nature, 2014, 514:575

Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito H, Tsuji K, Sekiya I

Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits

Arthritis Res Ther, 2010, 12:R206

Miyazaki M, Zuk PA, Zou J, Yoon SH, Wei F, Morishita Y, Sintuu C, Wang JC

Comparison of human mesenchymal stem cells derived from adipose tissue and bone marrow for ex vivo gene therapy in rat spinal fusion model

Spine, 2008, 33:863

Mizumo H, Tobita M, Uysal AC

Concise review. Adipose-derived stem cells as a novel tool for future regenerative medicine

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Moon SH, Gilbertson LG, Nishida K, Knaub M, Muzzonigro T, Robbins PD, Evans CH, Kang JD

Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer. Implications for the clinical management of intervertebral disc disorders

Spine, 2000, 25:2573

Moore KA, Lemischka IR

Stem cells and their niches

Science, 2006, 311:1880

Moore KR, Pinto MR, Butler LM

Degenerative disc disease treated with combined anterior and posterior arthrodesis and posterior instrumentation

Spine, 2002, 27:1680

Moore RJ, Latham JM, Vernon-Roberts B, Fraser RD

Does plate fixation prevent disc degeneration after a lateral anulus tear?

Spine, 1994, 19:2787

Morishita Y, Ohta H, Naito M, Matsumoto Y, Huang G, Tatsumi M, Takemitsu Y, Kida H

Kinematic evaluation of the adjacent segments after lumbar instrumented surgery. A comparison between rigid fusion and dynamic non-fusion stabilization

Eur Spine J, 2011, 20:1480

Morrison SJ, Csete M, Groves AK, Melega W, Wold B, Anderson DJ

Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells

J Neurosci, 2000, 20:7370

Moskovitz PA

Minimally invasive posterolateral lumbar arthrodesis

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Moumene M, Geisler FH

Comparison of biomechanical function at ideal and varied surgical placement for two lumbar artificial disc implant designs. Mobile-core versus fixed-core

Spine, 2007, 32:1840

Mulholland RC

The myth of lumbar instability. The importance of abnormal loading as a cause of low back pain

Eur Spine J 2008, 17:619

Mulholland RC, Sengupta DK

Rationale, principles and experimental evaluation of the concept of soft stabilization.
Eur Spine J, 2002, 11(Suppl 2):S198

Müller-Ladner U, Roberts CR, Franklin BN, Gay RE, Robbins PD, Evans CH, Gay S

Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective

J Immunol,1997, 158:3492

Muschler GF, Boehm C, Easley K 

Aspiration to obtain osteoblast progenitor cells from human bone marrow. The influence of aspiration volume

J Bone Joint Surg, 1997, 79A:1699

Muschler GF, Matsukura Y, Nitto H, Boehm CA, Valdevit AD, Kambic HE, Davros WJ, Easley KA, Powell KA

Selective retention of bone marrow-derived cells to enhance spinal fusion

Clin Orthop Related Res, 2005, 432:242

Muschler GF, Midura RJ

Connective tissue progenitors. Practical concepts for clinical applications

Clin Orthop Relat Res, 2002, 395:66

Muschler GF, Midura RJ, Nakamoto C

Practical modeling concepts for connective tissue stem cell and progenitor compartment kinetics

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Muschler GF, Nakamoto C, Griffith LG

Engineering principles of clinical cell-based tissue engineering

J Bone Joint Surg, 2004, 86A:1541

Muschler GF, Nakamoto C, Griffith LG

Engineering principles of clinical cell-based tissue engineering. Current concepts Review

J Bone Joint Surg, 2004, 86A:1541

Muschler GF, Nitto H, Boehm CA, Easley KA

Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors

J Orthop Res, 2001, 19:117

Muschler GF, Nitto H, Matsukura Y, Boehm C, Valdevit A, Kambic H, Davros W, Powell K, Easley K

Spine fusion using cell matrix composites enriched in bone marrow-derived cells

Clin Orthop Relat Res, 2003, 407:102

Mwale F, Roughley P, Antoniou J

Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage. A requisite for tissue engineering of intervertebral disc

Eur Cell Mater, 2004, 8:58

Myers MA, Casciani T, Whitbeck MG Jr, Puzas JE

Vertebral body osteopenia associated with posterolateral spine fusion in humans
Spine, 1996, 21:2368


Nachemson A

Some mechanical properties of the lumbar intervertebral discs

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Nachemson A

The load on lumbar disks in different positions of the body

Clin Orthop Related Res, 1966, 45:107

Nachemson A

The lumbar spine. An orthopaedic challenge

Spine, 1976, 1:9

Nachemson A

Towards a better understanding of low-back pain. A review of the mechanics of the lumbar disc
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Nachemson A

Work for all. For those with low back pain as well

Clin Orthop Relat Res, 1983, 179:77

Nachemson A, Zdeblick TA, O'Brien JP

Lumbar disc disease with discogenic pain. What surgical treatment is most effective?

Spine, 1996, 21:1835

Nagae M, Ikeda T, Mikami Y, Hase H, Ozawa H, Matsuda K, Sakamoto H, Tabata Y, Kawata M, Kubo T

Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres

Tissue Eng, 2007, 13:147

Nagano T, Yonenobu K, Miyamoto S, Tohyama M, Ono K

Distribution of the basic fibroblast growth factor and its receptor gene expression in normal and degenerated rat intervertebral discs

Spine, 1995, 20:1972

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Comprehensive assessment of chronic low back pain patients and controls. Physical abilities, level of activity, psychological adjustment and pain perception

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Effect of annular incision type on the change in biomechanical properties in a herniated lumbar intervertebral disc

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Intraspinal therapy using methylprednisolone acetate. Twenty-three years of clinical controversy

Spine, 1993, 18:278

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Expression of fibronectin and TGF-beta1 mRNA and protein suggest altered regulation of extracellular matrix in degenerated disc tissue

Eur Spine J, 2005, 14:17

Nerurkar NL, Elliott DM, Mauck RL

Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering

J Orthop Res, 2007, 25:1018

Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL

Engineered disc-like angle-ply structures for intervertebral disc replacement

Spine, 2010, 35:867

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TGF-β1 calcium signaling increases α5 integrin expression in osteoblasts

J Orthop Res, 2002, 20:1042

Nesti LJ, Li WJ, Shanti RM, Jiang YJ, Jackson W, Freedman BA, Kuklo TR, Giuliani JR, Tuan RS

Intervertebral disc tissue engineering using a novel hyaluronic acid–nanofibrous scaffold (HANFS) amalgam

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Effect of degeneration of the intervertebral disk on the process of diffusion

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Radiofrequency denervation for neck and back pain. A systematic review within the framework of the cochrane collaboration back review group

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Sustained transgene expression in intervertebral disc cells in vivo mediated by microbubble-enhanced ultrasound gene therapy

Spine, 2006, 31:1415

Nishida K, Gilbertson LG, Robbins PD, Evans CH, Kang JD

Potential applications of gene therapy to the treatment of intervertebral disc disorders

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Nishida K, Kang JD, Gilbertson LG, Moon SH, Suh JK, Vogt MT, Robbins PD, Evans CH

Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy. An in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene

Spine, 1999, 24:2419

Nishida K, Kang JD, Suh JK, Robbins PD, Evans CH, Gilbertson LG

Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration

Spine, 1998, 23:2437

Nishida K, Suzuki T, Kakutani K, Yurube T, Maeno K, Kurosaka M, Doita M

Gene therapy approach for disc degeneration and associated spinal disorders

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Spine, 1998, 23:1531

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Dynamic stabilization in the surgical management of painful lumbar spinal disorders

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Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells

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Nohe A, Keating E, Knaus P, Petersen NO

Signal transduction of bone morphogenetic protein receptors

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Nordin M, Balagué F, Cedraschi C

Nonspecific lower-back pain. Surgical versus nonsurgical treatment

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Spinal cord stimulation versus repeated lumbosacral spine surgery for chronic pain. A randomized, controlled trial

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Nöth U, Osyczka AM, Tuli R, Hickok NJ, Danielson KG, Tuan RS 

Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells

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Nomura T, Göritz C, Catchpole T, Henkemeyer M, Frisén J

EphB signaling controls lineage plasticity of adult neural stem cell niche cells

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Nomura T, Mochida J, Okuma M, Nishimura K, Sakabe K

Nucleus pulposus allograft retards intervertebral disc degeneration.

Clin Orthop Relat Res, 2001, 389:94


Oaklander AL, North RB

Failed back surgery syndrome

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Does spinal kyphotic deformity influence the biomechanical characteristics of the adjacent motion segments? An in vivo animal model
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Oehme D, Goldschlager T, Rosenfeld JV, Ghosh P, Jenkin G

The role of stem cell therapies in degenerative lumbar spine disease. A review

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Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease. A Systematic Review of Animal Studies and Human Clinical Trials

Stem Cells Int, 2015, doi: 10.1155/2015/946031

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Tissue-engineering approach to regenerating the intervertebral disc

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The variable somatic genome

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Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro

J Periodontol, 2003, 74:849

Okuda S, Myoui A, Ariga K, Nakase T, Yonenobu K, Yoshikawa H

Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells

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A new approach to the treatment of chronic low back pain

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Intervertebral disc repair by autologous mesenchymal bone marrow cells. A pilot study

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Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs

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Anulus tears and intervertebral disc degeneration. An experimental study using an animal model. 1990 Volvo Award in experimental studies

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